Effect of Sodium Selenite on Kidney Function Test of Rabbits
This study was conducted to evaluate the effect of Sodium Selenite at different dosage levels mixed with water in rabbit. Fifteen rabbits (120 day old) were purchased from Tolinton market, Lahore. They were divided into three groups having three replicas (5 rabbits each). One group was kept as un-medicated control A. While the other Groups such as B and C were medicated with sodium selenite in a single dose at the rate of 2 and 3 mg/kg of body mass mixed in water for 20 days consecutively. Control diet Group â€œAâ€ received basal diet without any supplementation. Blood samples were collected on 1st, 7th, 14th, 21st and 28th day of dietry treatment from each group. Various serological parameters of kidney functioning enzymes (RFT) such as Creatinine and Urea were determined by using Semi automated Chemistry Analyzer. A significant increase in Creatinine and Urea levels (p<0.05) in rabbits of various treated groups was recorded after applying statistical ANOVA test. The results revealed that Sodium selenite alters the serum creatinine and urea levels by affecting the kidney and cause renal toxicity in rabbits.
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