PSM Biological Research 2022-04-30T00:00:00+00:00 PSM Biological Research Open Journal Systems <p style="text-align: justify;">PSM Biological Research (ISSN; 2517-9586) is a peer-reviewed, open access, multidisciplinary,&nbsp; international journal that publishes research on all aspects of biology and allied sciences.</p> Potential Therapeutic Benefits of Prophetic Medicine-Nigella sativa: A Review 2022-03-22T00:13:43+00:00 Sumama Farooq Mehwish Saleem Zunaira Azam Saneela Kausar <p><em>Nigella sativa</em> belongs to the Ranunculaceae family and it is also known as Kalonji, black cumin seed, black seed, Habbatul Barakah, Habbatus Sauda, etc. It is widely cultivated in different parts of the world and is an annual herb in Pakistan. It contains proteins, fats, carbohydrates, crude fiber, and ash found mostly in seed oil. Different kinds of vitamins and minerals (Cu, P, Zn, Fe), alkaloids, and some other compounds (citronellol, carvone, and limonene) are also found in it. Black seeds are commonly used as spice and flavoring agents. It is used in herbal medicine for its pharmacological actions like antihypertensive, liver tonics, diuretics, anti-diarrheal, appetite-stimulating, analgesics, anti-bacterial, antiviral, antidiabetic, anticancer, immunomodulator, anti-inflammatory, spasmolytic, bronchodilator, hepato-protective, renal-protective, gastro-protective, and antioxidant properties. This review aims to investigate the potential therapeutic benefits of <em>N. sativa</em>. Due to the phytochemical composition and pharmacological properties, the seed and seed oil from this plant can be considered good candidates to formulate new therapeutic agents.</p> 2022-03-22T00:00:00+00:00 Copyright (c) 2022 PSM Potassium Response against Incidence of Cotton Leaf Curl Virus Disease and its Effect on Seed Cotton Yield 2022-03-04T09:51:45+00:00 Abdullah Keerio Bushra Urooj Panhwar Vishandas Suthar Abdul Wahab Soomro Nargis Shah <p>Seed cotton yield is being declined because of several environmental stresses (biotic and abiotic). Among these stresses, cotton leaf curl virus disease has caused a severe threat to the production of cotton crops in Pakistan. In this connection, a field experiment was conducted at Central Cotton Research Institute, Sakrand, Sindh for two consecutive years to determine response of potassium (K) nutrition against the infestation of CLCuV disease and seedcotton yield. The experiment was designed in randomized complete block (RCBD) with four replications. Three potassium were applied 0 (control), 50, 100, and 150 kg K<sub>2</sub>O ha<sup>-1</sup>. A basal dose of 170-60 kg N: P205 ha-1 was common to all the replications and the cultivar was Bt.CRIS-508. The results showed that yield and its related components i.e. boll formation plant-1, boll weight, and seed index were significantly improved by the addition of K application and were observed highest with the application of 150 kg K2O ha-1 on both consecutive years. Data for K concentration in different plant parts differed significantly and increased linearly with increasing K-level. Potassium concentration increased linearly with increasing K-levels. The absorption of K by various plant parts increased with a concurrent increase in varying levels of K-fertilizer. An averaged across levels, the relative K concentration in plant parts was found in decreasing in order of leaves, burs, stem, seed, and lint. Results for the incidence of CLCuV disease significantly reduced due to K levels. The K fertilizer application resulted in the reduction of CLCuV disease spread at its mild infection levels.</p> 2022-03-04T00:00:00+00:00 Copyright (c) 2022 PSM Role of Quercetin against Polychlorinated Biphenyl (Aroclors 1242 and 1254) induced Changes in Biochemical Parameters and Antioxidant Status in Liver, Kidney, Brain, Heart and Testes of Rats 2022-03-24T16:01:04+00:00 Sarah Samir Othman Medhat Haroun Mokhtar Ibrahim Yousef <p>Polychlorinated biphenyls (PCBs) are lipophilic environmental pollutants that have been found in practically every component of the world's ecosystem as contaminants. PCBs have been proven to induce lipid peroxidation via causing oxidative damage to biomolecules, antioxidant enzyme regulation, and oxidative stress. In this research, we looked into the effect of quercetin on the antioxidant status of PCBs(Aroclors 1242 and 1254)-induced toxicity in male rats. The protective role of quercetin (50&nbsp;mg/kg body weight/day) was evaluated in the mixture of Aroclors 1242 and 1254-induced toxicity in rat blood, liver, kidney, brain, lung, heart, and testes. Animals were classified into four equal groups, control, quercetin (50 mg/kg BW), the mixture of Aroclors 1242 and 1254 (1:1, 2 mg/ kg body weight/day), and quercetin plus the mixture of aroclors, respectively. The respective doses of quercetin and the mixture of Aroclors were orally treated daily for 30 days. The mixture of aroclors induced an increase in plasma, liver, kidney, brain, lung, heart, and testes thiobarbituric acid reactive substances (TBARS), while the activities of antioxidant enzymes (GST, SOD, and GPx) were decreased. Transaminases and phosphatases were elevated in plasma and decreased in liver. Aroclors increased glucose, urea, and creatinine, while decreased immunoglobulin G (IgG), total protein, albumin, globulin, and bilirubin. Quercetin alone reduced TBARS, urea, creatinine, and bilirubin and increased antioxidant enzymes. The presence of quercetin with the mixture of Aroclors minimized its toxicity. In conclusion, administration of quercetin with 1242 and 1254 Aroclors mixture may alleviate its harmful effects.</p> 2022-03-24T00:00:00+00:00 Copyright (c) 2022 PSM